oxiconazole
Regulatory sources consulted
Approved indications
- Topical treatment of tinea pedis, cruris, or corporis and tinea versicolor.
Contraindications
Absolute
- Hypersensitivity to any cream component.
Clinical warnings
- Do not use ophthalmically or intravaginally. — openFDA oxiconazole nitrate cream 1% set ID 04477378-cccc-4db3-9e1b-5c1d6a00bd13
- Discontinue if sensitivity or irritation develops. Avoid contact with the nose, mouth and other mucous membranes, and do not apply under occlusion. — openFDA oxiconazole nitrate cream 1% set ID 04477378-cccc-4db3-9e1b-5c1d6a00bd13
Adverse events
Common (≥1%)
Itching · Burning · Irritation
Pregnancy and lactation
Use during pregnancy only if clearly needed. Oxiconazole is excreted in human milk; use cautiously while breastfeeding.
Recent literature (PubMed)
Oxime ethers are a class of compounds containing the >C=N-O-R moiety. The presence of this moiety affects the biological activity of the compounds. In this review, the structures of oxime ethers with specific biological activity have been collected and presented, and bactericidal, fungicidal, antidepressant, anticancer and herbicidal activities, among others, are described. The review includes both those substances that are currently used as drugs (e.g., fluvoxamine, mayzent, ridogrel, oxiconazole), as well as non-drug structures for which various biological activity studies have been conducted. To the best of our knowledge, this is the first review of the biological activity of compounds containing such a moiety. The authors hope that this review will inspire scientists to take a greater interest in this group of compounds, as it constitutes an interesting research area.