oxytetracycline
Regulatory sources consulted
Approved indications
- In adults and children older than 12 years, superficial skin infections caused by susceptible organisms.
Contraindications
Absolute
- Hypersensitivity to oxytetracycline, polymyxin B, or any excipient.
Clinical warnings
- Major warning · Risk of cross-sensitization with other tetracyclines, photosensitivity, and overgrowth of nonsusceptible organisms. For cutaneous use only; do not apply to damaged skin, wounds, large areas, eyes, ears, or mucosae. — CIMA TERRAMICINA 30 mg/g + 10.000 UI/g pomada, registro 19650
- Contact dermatitis, skin hyperpigmentation, hypersensitivity, and photosensitivity have been reported with unknown frequency; discontinue for an allergic reaction. Tooth discoloration has also been reported in pediatric patients with unknown frequency. — CIMA TERRAMICINA 30 mg/g + 10.000 UI/g pomada, registro 19650
Pregnancy and lactation
During pregnancy, use only if the clinical condition requires oxytetracycline/polymyxin B. During breastfeeding, decide whether to stop breastfeeding or treatment according to benefits and risks.
Recent literature (PubMed)
There are anywhere from 5 to 8 priority antibiotics in typical wastewater treatment plants (WWTPs) whose concentrations exceed the maximum allowed, out of 12 priority antibiotics designated by the World Health Organization as the species to pose severe health hazard than others. If the priority antibiotics to deal with could be reduced to just one or two, such reduction would greatly simplify the construction and operation of the treatment plants. Introduced here is a concept of 'primary' antibiotic, the abatement of which ensures mitigation of all the other priority antibiotics in the wastewater. A criterion for determining primary antibiotic is developed. For a demonstration of the approach, the wastewater systems treated with solar-based photocatalysts are considered. The criterion reveals that the primary antibiotic in the typical European WWTP as well as in the typical municipal and hospital wastewater is ciprofloxacin, whereas the typical industrial wastewater contains ciprofloxacin and oxytetracycline.
Growers have depended on the specificity and efficacy of streptomycin and oxytetracycline as a part of their plant disease arsenal since the middle of the 20th century. With climate change intensifying plant bacterial epidemics, the established success of these antibiotics remains threatened. Our strong reliance on certain antibiotics for devastating diseases eventually gave way to resistance development. Although antibiotics in plant agriculture equal to less than 0.5% of overall antibiotic use in the United States, it is still imperative for humans to continue to monitor usage, environmental residues, and resistance in bacterial populations. This review provides an overview of the history and use, resistance and mitigation, regulation, environmental impact, and economics of antibiotics in plant agriculture. Bacterial issues, such as the ongoing Huanglongbing (citrus greening) epidemic in Florida citrus production, may need antibiotics for adequate control. Therefore, preserving the efficacy of our current antibiotics by utilizing more targeted application methods, such as trunk injection, should be a major focus. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY 4.0 International license.